System Modeler

Posted on Feb 7, 2014

Wolfram SystemModeler ships with model libraries for a large selection of domains such as electronics, mechanics, and biochemistry. Now I am pleased to present a new library in the family, the SystemDynamics library by FranG§ois E. Cellier and Stefan Fabricius. System dynamics, a methodology developed by Jay Forrester in the `60s and `70s, is wel

System Modeler
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l suited for understanding the dynamics of large-scale systems with diverse components. It has been famously applied by the Club of Rome to investigate the limits of human growth; other applications include production management, life sciences, and economics (some showcases of the methodology can be found here ). Yesterday, the Nobel Prize in Chemistry was awarded to Robert J. Lefkowitz and Brian K. Kobilka for having mapped how a family of cellular receptors called G-protein-coupled receptors (GPCRs) work. The Nobel Prize winners` research has proven to be very important in the development of novel therapeutic drugs ”about 40 50% of all therapeutic drugs in use today are centered on GPCRs. The real beauty of GPCR-based response systems is that they include components that are used over and over again for the response to external signals in many kinds of cellular functions throughout our bodies. Sight, smell, and the adrenaline response are examples of these GPCR-mediated responses with physiologically important functions. Identifying new targets for therapeutic drug intervention includes analysis of the complex webs of signaling pathways and feedback systems in our cells, extending beyond the first event of a signal connecting with the GPCR on the cell surface, which is non-trivial. Lately the cost-effective practice of using mathematical models as an initial step for finding those elusive new targets, and also as a tool...

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